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Article

Impact of Polygenic Risk Scores on Retinal Microstructures in Early and Intermediate Age-related Macular Degeneration: the Northern Ireland Sensory Aging Study.

Eye (London, England) - 1 Aug 2025

Tang Fangyao, Hogg Ruth E, Higgins Bethany E, Wright David M, Smyth Laura, Sivaprasad Sobha

Abstract excerpt

BACKGROUND: Although polygenic risk scores (PRSs) have been developed for age-related macular degeneration (AMD), it is not known whether these scores are associated with changes of retinal microstructures in early AMD. We compared retinal microstructures due to age-related changes in eyes with healthy macula in people aged 55 years or above versus those with early AMD and then determined the associations of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40442413
DOI: 10.1038/s41433-025-03844-9
PMCID: PMC12325789

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RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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