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Polygenic Risk Score Impact on Visual Function in Older Individuals with Healthy Macula: The Northern Ireland Sensory Ageing Study.

Eye (London, England) - 1 Jun 2025

Tang Fangyao, Hogg Ruth E, Higgins Bethany E, Wright David M, Smyth Laura, Sivaprasad Sobha

Abstract excerpt

BACKGROUND/OBJECTIVES: Although polygenic risk scores (PRSs) have been developed for age-related macular degeneration (AMD), it is not known whether these scores are associated with impairment of visual functions in older individuals with healthy macula. We evaluated age-related changes in visual function in people aged 55 years or above with healthy macula and determined the associations of age-related visual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39962206
DOI: 10.1038/s41433-025-03642-3
PMCID: PMC12089396

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