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Article

Predictive Performance of an Updated Polygenic Risk Score for Age-Related Macular Degeneration.

Ophthalmology - 1 Aug 2024

Yu Chenglong, Robman Liubov, He Weixiong, Woods Robyn L, Phuong Thao Le Thi, Wolfe Rory, Phung James, Makeyeva Galina A, Hodgson Lauren A B, McNeil John J, Guymer Robyn H, MacGregor Stuart, Lacaze Paul

Abstract excerpt

PURPOSE: A recent genome-wide association study of age-related macular degeneration (AMD) identified new AMD-associated risk variants. These variants now can be incorporated into an updated polygenic risk score (PRS). This study aimed to assess the performance of an updated PRS, PRS2023, in an independent cohort of older individuals with retinal imaging data and to compare performance with an older PRS, PRS2016....

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Identifiers

PMID: 38307466
DOI: 10.1016/j.ophtha.2024.01.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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