Article
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
PloS one - 1 Jan 2013
Holliday Elizabeth G, Smith Albert V, Cornes Belinda K, Buitendijk Gabriëlle H S, Jensen Richard A, Sim Xueling, Aspelund Thor, Aung Tin, Baird Paul N, Boerwinkle Eric, Cheng Ching Yu, van Duijn Cornelia M, Eiriksdottir Gudny, Gudnason Vilmundur, Harris Tamara, Hewitt Alex W, Inouye Michael, Jonasson Fridbert, Klein Barbara E K, Launer Lenore, Li Xiaohui, Liew Gerald, Lumley Thomas, McElduff Patrick, McKnight Barbara, Mitchell Paul, Psaty Bruce M, Rochtchina Elena, Rotter Jerome I, Scott Rodney J, Tay Wanting, Taylor Kent, Teo Yik Ying, Uitterlinden André G, Viswanathan Ananth, Xie Sophia, Vingerling Johannes R, Klaver Caroline C W, Tai E Shyong, Siscovick David, Klein Ronald, Cotch Mary Frances, Wong Tien Y, Attia John, Wang Jie Jin
Abstract excerpt
Genetic factors explain a majority of risk variance for age-related macular degeneration (AMD). While genome-wide association studies (GWAS) for late AMD implicate genes in complement, inflammatory and lipid pathways, the genetic architecture of early AMD has been relatively under studied. We con...
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