Article

Liquid droplet aging and fibril formation of the stress granule protein TIA1 low complexity domain

2022-03-30

Abstract excerpt

<h4>SUMMARY</h4> Protein domains biased toward a few amino acid types are vital for the formation of biomolecular condensates in living cells. These membraneless compartments are formed by molecules exhibiting a range of molecular motions and structural order. Missense mutations increase condensate persistence lifetimes or structural order, properties that are thought to underlie pathological protein aggregation....

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Literature Corpus work: 62c05b62-8b21-5266-833f-fe4b5b06c622
DOI: 10.1101/2022.03.30.486471

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