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Article

The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2025

Xiang Yijin, Metayer Catherine, Kogan Scott C, Ma Xiaomei, Nickels Eric, Wiemels Joseph L

Abstract excerpt

BACKGROUND: Prenatal maternal folate intake is associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL), but how this interacts with children's genetic predisposition to folate deficiency remains unclear. METHODS: We used Mendelian randomization to investigate the causal link among serum folate, total homocysteine, and B vitamins on ALL using independent genetic instruments. These were...

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Identifiers

PMID: 40439753
DOI: 10.1158/1055-9965.EPI-25-0154
PMCID: PMC12515492

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