Article
Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics.
Cancer - 1 Dec 2016
Archer Natalie P, Perez-Andreu Virginia, Scheurer Michael E, Rabin Karen R, Peckham-Gregory Erin C, Plon Sharon E, Zabriskie Ryan C, De Alarcon Pedro A, Fernandez Karen S, Najera Cesar R, Yang Jun J, Antillon-Klussmann Federico, Lupo Philip J
Abstract excerpt
BACKGROUND: Children of Hispanic ancestry have a higher incidence of acute lymphoblastic leukemia (ALL) compared with other ethnic groups, but to the authors' knowledge, the genetic basis for these racial disparities remain incompletely understood. Genome-wide association studies of childhood ALL to date have focused on inherited genetic effects; however, maternal genetic effects (the role of the maternal...
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