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Article

Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.

Blood - 5 Mar 2009

de Jonge Robert, Tissing Wim J E, Hooijberg Jan Hendrik, Jansen Gerrit, Kaspers Gertjan J L, Lindemans Jan, Peters Godefridus J, Pieters Rob

Abstract excerpt

Polymorphisms in folate pathway genes may influence the susceptibility to acute lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) and from 500 blood bank donors (controls). Polymorphisms in methylene-tetrahydrofolate reductase (MTHFR 677C>T, 1298A>C), methionine synthase (MTR 2756A>G), methionine synthase reductase (MTRR 66A>G), methylenetetrahydrofolate dehydrogenase (MTHFD1...

Read the complete abstract on PubMed

Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Ferredoxin-NADP Reductase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Glycine Hydroxymethyltransferase

Share to Membrane Transport Proteins

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Thymidylate Synthase

Source

Identifiers

PMID: 19020309
DOI: 10.1182/blood-2008-07-165928

Genes

NNMT
RFC1
MTHFR
MTHFD1
MTR
MTRR
SHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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