Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian randomization approaches.

Genome medicine - 15 May 2025

Leyden Genevieve M, Sobczyk Maria K, Richardson Tom G, Gaunt Tom R

Abstract excerpt

BACKGROUND: Mendelian randomization (MR) leverages trait associated genetic variants as instrumental variables (IVs) to determine causal relationships in epidemiology. However, genetic IVs for complex traits are typically highly heterogeneous and, at a molecular level, exert effects on different biological processes. Exploration of the biological underpinnings of such heterogeneity can enhance our understanding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40375348
DOI: 10.1186/s13073-025-01472-2
PMCID: PMC12079859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian randomization approaches.PMID 40375348Read ↗

Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian Randomization approachesSemantic proximity Read ↗

Inferring Multi-Organ Genetic Causal Connections using Imaging and Clinical Data through Mendelian RandomizationSemantic proximity Read ↗

METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Semantic proximity Read ↗

Exploring the Causal Relationship Between Body Mass Index and Kidney Function Using Tissue-Partitioned Mendelian RandomizationSemantic proximity Read ↗

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization StudySemantic proximity Read ↗

Mendelian randomization of plasma lipidome, inflammatory proteome and heart failure.Semantic proximity Read ↗

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read ↗

Multiomics Mendelian Randomization of GWAS, eQTL, and pQTL Combined With Drug Analysis to Predict Drug Targets in Myocardial Infarction.Semantic proximity Read ↗

An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.Semantic proximity Read ↗

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomizationSemantic proximity Read ↗

A multi-tissue mendelian randomization method based on eQTL data for mapping tissue-specific disease genes.Semantic proximity Read ↗

Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: Application of cis-multivariable Mendelian randomization to GLP1R gene region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.