Article
Loss of Heterozygosity associated with ubiquitous environments in yeast.
PLoS genetics - 1 May 2025
Vijayan Nikilesh, Joshi Sameer, Sarath Praseetha, Nishant Koodali T
Abstract excerpt
The effect of ubiquitous environmental conditions on mutational mechanisms, particularly loss of heterozygosity (LOH) remains poorly understood. Environment induced LOH can rapidly alter the genome and promote disease progression. Using mutation accumulation (MA) lines, we analysed the effect of ubiquitous environmental conditions on mutational mechanisms in a diploid hybrid (S288c/YJM789) baker's yeast strain....
Read the complete abstract on PubMedTopics
- Loss of Heterozygosity
- Saccharomyces cerevisiae
- Oxidative Stress
- Mutation
- Genome, Fungal
- Light
- Environment