Loss of Heterozygosity and Its Importance in Evolution.

doi:10.1007/s00239-022-10088-8

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Article

Loss of Heterozygosity and Its Importance in Evolution.

Journal of molecular evolution - 1 Jun 2023

Smukowski Heil Caiti

Abstract excerpt

Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread in organisms that have asexual reproduction like budding yeasts, and is also an important and frequent mutation event in tumorigenesis. Mutation accumulation studies have demonstrated that LOH occurs at a rate higher than the point mutation rate, and can impact large...

Topics

Saccharomyces cerevisiae
Mutation
Loss of Heterozygosity
Mutation Rate
Genome

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Identifiers

PMID: 36752826
DOI: 10.1007/s00239-022-10088-8
PMCID: PMC10276065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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