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Article

Multi-ancestry sequencing-based genome-wide association study of C-reactive protein in 513,273 genomes.

Nature communications - 24 Apr 2025

Li Hongru, Zhao Jingyi, Dai Jinglan, You Dongfang, Zhao Yang, Christiani David C, Chen Feng, Shen Sipeng

Abstract excerpt

C-reactive protein (CRP) serves as a pivotal marker of systemic inflammation, yet its genetic architecture has predominantly been explored within European populations. Our multi-ancestry sequencing-based genome-wide association study (seqGWAS) meta-analysis encompasses 447,369 Europeans, 10,389 Africans, 9685 Asians, and 9200 Hispanics in the discovery set, and 23,521 Europeans, 7160 Africans, 771 Asians, and...

Read the complete abstract on PubMed

Topics

Female
Humans
Male
Asian People
C-Reactive Protein
Genome, Human
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hispanic or Latino

Multifactorial Inheritance

Polymorphism, Single Nucleotide

White People

African People

Source

Open in PubMed Open full text

Identifiers

PMID: 40274876
DOI: 10.1038/s41467-025-59155-w
PMCID: PMC12022081

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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