Article
Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts.
American journal of human genetics - 2 Jan 2020
Raffield Laura M, Iyengar Apoorva K, Wang Biqi, Gaynor Sheila M, Spracklen Cassandra N, Zhong Xue, Kowalski Madeline H, Salimi Shabnam, Polfus Linda M, Benjamin Emelia J, Bis Joshua C, Bowler Russell, Cade Brian E, Choi Won Jung, Comellas Alejandro P, Correa Adolfo, Cruz Pedro, Doddapaneni Harsha, Durda Peter, Gogarten Stephanie M, Jain Deepti, Kim Ryan W, Kral Brian G, Lange Leslie A, Larson Martin G, Laurie Cecelia, Lee Jiwon, Lee Seonwook, Lewis Joshua P, Metcalf Ginger A, Mitchell Braxton D, Momin Zeineen, Muzny Donna M, Pankratz Nathan, Park Cheol Joo, Rich Stephen S, Rotter Jerome I, Ryan Kathleen, Seo Daekwan, Tracy Russell P, Viaud-Martinez Karine A, Yanek Lisa R, Zhao Lue Ping, Lin Xihong, Li Bingshan, Li Yun, Dupuis Josée, Reiner Alexander P, Mohlke Karen L, Auer Paul L
Abstract excerpt
Whole-genome sequencing (WGS) can improve assessment of low-frequency and rare variants, particularly in non-European populations that have been underrepresented in existing genomic studies. The genetic determinants of C-reactive protein (CRP), a biomarker of chronic inflammation, have been extensively studied, with existing genome-wide association studies (GWASs) conducted in >200,000 individuals of European...
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