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Article

Association of exome sequences with plasma C-reactive protein levels in >9000 participants.

Human molecular genetics - 15 Jan 2015

Schick Ursula M, Auer Paul L, Bis Joshua C, Lin Honghuang, Wei Peng, Pankratz Nathan, Lange Leslie A, Brody Jennifer, Stitziel Nathan O, Kim Daniel S, Carlson Christopher S, Fornage Myriam, Haessler Jeffery, Hsu Li, Jackson Rebecca D, Kooperberg Charles, Leal Suzanne M, Psaty Bruce M, Boerwinkle Eric, Tracy Russell, Ardissino Diego, Shah Svati, Willer Cristen, Loos Ruth, Melander Olle, Mcpherson Ruth, Hovingh Kees, Reilly Muredach, Watkins Hugh, Girelli Domenico, Fontanillas Pierre, Chasman Daniel I, Gabriel Stacey B, Gibbs Richard, Nickerson Deborah A, Kathiresan Sekar, Peters Ulrike, Dupuis Josée, Wilson James G, Rich Stephen S, Morrison Alanna C, Benjamin Emelia J, Gross Myron D, Reiner Alex P

Abstract excerpt

C-reactive protein (CRP) concentration is a heritable systemic marker of inflammation that is associated with cardiovascular disease risk. Genome-wide association studies have identified CRP-associated common variants associated in ∼25 genes. Our aims were to apply exome sequencing to (1) assess whether the candidate loci contain rare coding variants associated with CRP levels and (2) perform an exome-wide search...

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Source

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Identifiers

PMID: 25187575
DOI: 10.1093/hmg/ddu450
PMCID: PMC4334838

Genes

CRP
APOE
RORA
TOMM40

Variants

rs77832441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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