Article
Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study.
Human molecular genetics - 15 Aug 2018
Kocarnik Jonathan M, Richard Melissa, Graff Misa, Haessler Jeffrey, Bien Stephanie, Carlson Chris, Carty Cara L, Reiner Alexander P, Avery Christy L, Ballantyne Christie M, LaCroix Andrea Z, Assimes Themistocles L, Barbalic Maja, Pankratz Nathan, Tang Weihong, Tao Ran, Chen Dongquan, Talavera Gregory A, Daviglus Martha L, Chirinos-Medina Diana A, Pereira Rocio, Nishimura Katie, Bužková Petra, Best Lyle G, Ambite José Luis, Cheng Iona, Crawford Dana C, Hindorff Lucia A, Fornage Myriam, Heiss Gerardo, North Kari E, Haiman Christopher A, Peters Ulrike, Le Marchand Loic, Kooperberg Charles
Abstract excerpt
C-reactive protein (CRP) is a circulating biomarker indicative of systemic inflammation. We aimed to evaluate genetic associations with CRP levels among non-European-ancestry populations through discovery, fine-mapping and conditional analyses. A total of 30 503 non-European-ancestry participants from 6 studies participating in the Population Architecture using Genomics and Epidemiology study had serum...
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