C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

doi:10.1093/hmg/dds133

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Article

C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

Human molecular genetics - 1 Jul 2012

Doumatey Ayo P, Chen Guanjie, Tekola Ayele Fasil, Zhou Jie, Erdos Michael, Shriner Daniel, Huang Hanxia, Adeleye Jokotade, Balogun Williams, Fasanmade Olufemi, Johnson Thomas, Oli Johnnie, Okafor Godfrey, Amoah Albert, Eghan Benjamin A, Agyenim-Boateng Kofi, Acheampong Joseph, Adebamowo Clement, Gerry Norman P, Christman Michael F, Adeyemo Adebowale, Rotimi Charles N

Abstract excerpt

C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic factors, including infection and obesity. Genome-wide association studies (GWAS) provide an unbiased approach towards identifying loci influencing CRP levels. None of the six GWAS for CRP levels has been conducted in an African ancestry population. The...

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PMID: 22492993
DOI: 10.1093/hmg/dds133
PMCID: PMC3373247

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