Article
Mutational and co-mutational landscape of early onset colorectal cancer.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Feb 2025
Alshenaifi Jumanah Yousef, Vetere Guglielmo, Maddalena Giulia, Yousef Mahmoud, White Michael G, Shen John Paul, Vilar Eduardo, Parseghian Christine, Dasari Arvind, Morris Van Karlyle, Huey Ryan, Overman Michael J, Wolff Robert, Raghav Kanwal P, Willis Jason, Alfaro Kristin, Futreal Andy, You Y Nancy, Kopetz Scott
Abstract excerpt
INTRODUCTION: Colorectal cancer (CRC) incidence and mortality before 50 have been rising alarmingly in the recent decades. METHODS: Using a cohort of 10,000 patients, this study investigates the clinical, mutational, and co-mutational features of CRC in early-onset (EOCRC, < 50 years) compared to late-onset (LOCRC, ≥ 50 years). RESULTS: EOCRC was associated with a higher prevalence of Asian and Hispanic patients,...
Topics
- Humans
- Colorectal Neoplasms
- Female
- Middle Aged
- Male
- Mutation
- Age of Onset
- Aged
- Proto-Oncogene Proteins B-raf