Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

doi:10.14309/ajg.0000000000002171

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Article

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

The American journal of gastroenterology - 1 Apr 2023

Ugai Tomotaka, Haruki Koichiro, Harrison Tabitha A, Cao Yin, Qu Conghui, Chan Andrew T, Campbell Peter T, Akimoto Naohiko, Berndt Sonja, Brenner Hermann, Buchanan Daniel D, Chang-Claude Jenny, Fujiyoshi Kenji, Gallinger Steven J, Gunter Marc J, Hidaka Akihisa, Hoffmeister Michael, Hsu Li, Jenkins Mark A, Milne Roger L, Moreno Victor, Newcomb Polly A, Nishihara Reiko, Pai Rish K, Sakoda Lori C, Slattery Martha L, Sun Wei, Amitay Efrat L, Alwers Elizabeth, Thibodeau Stephen N, Toland Amanda E, Van Guelpen Bethany, Woods Michael O, Zaidi Syed H, Potter John D, Giannakis Marios, Song Mingyang, Nowak Jonathan A, Phipps Amanda I, Peters Ulrike, Ogino Shuji

Abstract excerpt

INTRODUCTION: Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal length, the prevalence of certain tumor molecular characteristics graduall...

Topics

Humans
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
DNA Methylation
Colorectal Neoplasms
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

CpG Islands

Microsatellite Instability

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Identifiers

PMID: 36707929
DOI: 10.14309/ajg.0000000000002171
PMCID: PMC10065351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-36707929-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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