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Article

Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.

Psychological medicine - 11 Apr 2025

Rami Fatima Zahra, Seo Hyungwoo, Kang Chaeyeong, Park Seunghwan, Li Ling, Le Thi-Hung, Kim Sung-Wan, Won Seung-Hee, Chung Wonil, Chung Young-Chul

Abstract excerpt

BACKGROUND: Emerging evidence indicates that gene-environment interactions (GEIs) are important underlying mechanisms for the development of schizophrenia (SZ). We investigated the associations of polygenic risk score for SZ (PRS-SZ), environmental measures, and their interactions with case-control status and clinical phenotypes among patients with schizophrenia spectrum disorders (SSDs). METHODS: The PRS-SZ for...

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Identifiers

PMID: 40211091
DOI: 10.1017/S0033291725000753
PMCID: PMC12094650

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