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Article

Gene-Environment Correlation Across Trauma Subtypes and Developmental Timing: Evidence From the EU-GEI and ALSPAC.

Biological psychiatry - 15 Sept 2026

Trotta Giulia, Austin-Zimmerman Isabelle, Spinazzola Edoardo, Haussler Senta, Sideli Lucia, Aas Monica, Rodriguez Victoria, Li Zhikun, Leung Perry B M, Li Qiang, Quattrone Diego, Morgan Craig, O'Donovan Michael, Sham Pak C, Vassos Evangelos, Wong Chloe C Y, Bentall Richard, Murray Robin M, Alameda Luis, Di Forti Marta

Abstract excerpt

BACKGROUND: Childhood trauma is a well-known environmental risk factor for psychiatric disorders, yet genetic influences may also shape exposure to adversity via gene-environment correlation (rGE). METHODS: We examined rGE between polygenic risk scores (PRSs) for psychiatric and behavioral traits and trauma subtypes across development in 2 large cohorts: the EU-GEI (European Network of National Schizophrenia...

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PMID: 41933711
DOI: 10.1016/j.biopsych.2026.03.1000

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