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Article

Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.

Translational psychiatry - 5 Aug 2026

Trotta Giulia, Austin-Zimmerman Isabelle, Spinazzola Edoardo, Sideli Lucia, Aas Monica, Rodriguez Victoria, Haussler Senta, Li Zhikun, Leung Perry Bm, Li Qiang, Quattrone Diego, Petrova Teya, Morgan Craig, O'Donovan Michael, Sham Pak C, Vassos Evangelos, Wong Chloe Cy, Bentall Richard, Murray Robin M, Alameda Luis, Di Forti Marta

Abstract excerpt

Psychotic disorders are complex, multifactorial conditions influenced by both genetic liability and early environmental adversity. Polygenic risk scores (PRSs) derived from genome-wide association studies have shown utility in capturing genetic predisposition, but their biological interpretability remains limited. In this study, we evaluated whether biologically informed pathway-specific polygenic scores (pPGSs)...

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Identifiers

PMID: 42586966
DOI: 10.1038/s41398-026-04317-7
PMCID: PMC13470413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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