Article
Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.
Schizophrenia bulletin - 8 Sept 2025
Rodriguez Victoria, Alameda Luis, Aas Monica, Gayer-Anderson Charlotte, Trotta Giulia, Spinazzola Edoardo, Quattrone Diego, Tripoli Giada, Jongsma Hannah E, Stilo Simona, La Cascia Caterina, Ferraro Laura, La Barbera Daniele, Lasalvia Antonio, Tosato Sarah, Tarricone Ilaria, Bonora Elena, Jamain Stéphane, Selten Jean-Paul, Velthorst Eva, de Haan Lieuwe, Llorca Pierre-Michel, Arrojo Manuel, Bobes Julio, Bernardo Miguel, Arango Celso, Kirkbride James, Jones Peter B, Rutten Bart P, Richards Alexander, Sham Pak C, O'Donovan Michael, Van Os Jim, Morgan Craig, Di Forti Marta, Murray Robin M, Vassos Evangelos
Abstract excerpt
BACKGROUND: Multiple genetic and environmental risk factors play a role in the development of both schizophrenia-spectrum disorders and affective psychoses. How they act in combination is yet to be clarified. METHODS: We analyzed 573 first episode psychosis cases and 1005 controls, of European ancestry. Firstly, we tested whether the association of polygenic risk scores for schizophrenia, bipolar disorder, and...
Read the complete abstract on PubMedTopics
- Humans
- Schizophrenia