Multiancestral polygenic risk score for pediatric asthma.

doi:10.1016/j.jaci.2022.03.035

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Multiancestral polygenic risk score for pediatric asthma.

The Journal of allergy and clinical immunology - 1 Nov 2022

Namjou Bahram, Lape Michael, Malolepsza Edyta, DeVore Stanley B, Weirauch Matthew T, Dikilitas Ozan, Jarvik Gail P, Kiryluk Krzysztof, Kullo Iftikhar J, Liu Cong, Luo Yuan, Satterfield Benjamin A, Smoller Jordan W, Walunas Theresa L, Connolly John, Sleiman Patrick, Mersha Tesfaye B, Mentch Frank D, Hakonarson Hakon, Prows Cynthia A, Biagini Jocelyn M, Khurana Hershey Gurjit K, Martin Lisa J, Kottyan Leah

Abstract excerpt

BACKGROUND: Asthma is the most common chronic condition in children and the third leading cause of hospitalization in pediatrics. The genome-wide association study catalog reports 140 studies with genome-wide significance. A polygenic risk score (PRS) with predictive value across ancestries has not been evaluated for this important trait. OBJECTIVES: This study aimed to train and validate a PRS relying on genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bayes Theorem

Share to Child

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 35595084
DOI: 10.1016/j.jaci.2022.03.035
PMCID: PMC9643615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiancestral polygenic risk score for pediatric asthma.PMID 35595084Read ↗

Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with AsthmaSemantic proximity Read ↗

Revealing polygenic pleiotropy using genetic risk scores for asthmaSemantic proximity Read ↗

A polygenic risk score for asthma in a large racially diverse population.Semantic proximity Read ↗

Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways.Semantic proximity Read ↗

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.Semantic proximity Read ↗

Deep learning and statistical methods identify novel asthma risk variants in Europeans.Semantic proximity Read ↗

Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversitySemantic proximity Read ↗

EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma.Semantic proximity Read ↗

Polygenic risk scores associate with asthma phenotypes and proteomic analyses implicate IL1R1 in two family-based studiesSemantic proximity Read ↗

Shared and Distinct Genetic Risk Factors for Childhood Onset and Adult Onset Asthma: Genome- and Transcriptome-wide StudiesSemantic proximity Read ↗

Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthmaSemantic proximity Read ↗

Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk predictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.