Article
Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1.
Cancer letters - 1 Oct 2021
Ma Ding, Zhan Daqian, Fu Yi, Wei Shuang, Lal Bachchu, Wang Jie, Li Yunqing, Lopez-Bertoni Hernando, Yalcin Fatih, Dzaye Omar, Eberhart Charles G, Laterra John, Wilson Mary Ann, Ying Mingyao, Xia Shuli
Abstract excerpt
Tumor-associated microglia/macrophages (TAMs) are the main innate immune effector cells in malignant gliomas and have both pro- and anti-tumor functions. The plasticity of TAMs is partially dictated by oncogenic mutations in tumor cells. Heterozygous IDH1 mutation is a cancer driver gene prevalent in grade II/III gliomas, and IDH1 mutant gliomas have relatively favorable clinical outcomes. It is largely unknown...
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