A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas.

doi:10.1002/ijc.35441

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Article

A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas.

International journal of cancer - 1 Aug 2025

Chouleur Tiffanie, Etchegaray Christèle, Villain Laura, Lesur Antoine, Ferté Thomas, Rossi Marco, Andrique Laetitia, Simoncini Costanza, Giacobbi Anne-Sophie, Gambaretti Matteo, Lopci Egesta, Fernades Bethania, Dittmar Gunnar, Bjerkvig Rolf, Hejblum Boris, Thiébaut Rodolphe, Saut Olivier, Bello Lorenzo, Bikfalvi Andreas

Abstract excerpt

Isocitrate dehydrogenase-mutant gliomas are lethal brain cancers that impair quality of life in young adults. Although less aggressive than glioblastomas, IDH-mutant gliomas invariably progress to incurable disease with unpredictable recurrence. A better classification of patient risk of recurrence is needed. Here, we describe a multimodal analytical pipeline integrating imaging, transcriptomic, and proteomic...

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PMID: 40214613
DOI: 10.1002/ijc.35441
PMCID: PMC12141979

Genes

ATXN10
EIF4H
ITGAV
KRT19
NCAM1
RUNX3
SCRT2

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