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Article

Suppression of antitumor immune signatures and upregulation of VEGFA as IDH-mutant gliomas progress to higher grade.

Neurosurgical focus - 1 Feb 2024

Grewal Eric P, Richardson Leland G K, Sun Jing, Ramapriyan Rishab, Martinez-Lage Maria, Miller Julie J, Cahill Daniel P, Choi Bryan D, Curry William T

Abstract excerpt

OBJECTIVE: Several studies have compared the immune microenvironment of isocitrate dehydrogenase (IDH)-wildtype glioma versus IDH-mutant glioma. The authors sought to determine whether histological tumor progression in a subset of IDH-mutant glioma was associated with concomitant alterations in the intratumoral immune microenvironment. METHODS: The authors performed bulk RNA sequencing on paired and unpaired...

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Source

Identifiers

PMID: 38301244
DOI: 10.3171/2023.11.FOCUS23694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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