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Article

Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas.

Cell reports. Medicine - 21 Nov 2023

Blanco-Carmona Enrique, Narayanan Ashwin, Hernandez Inmaculada, Nieto Juan C, Elosua-Bayes Marc, Sun Xueyuan, Schmidt Claudia, Pamir Necmettin, Özduman Koray, Herold-Mende Christel, Pagani Francesca, Cominelli Manuela, Taranda Julian, Wick Wolfgang, von Deimling Andreas, Poliani Pietro Luigi, Rehli Michael, Schlesner Matthias, Heyn Holger, Turcan Şevin

Abstract excerpt

The isocitrate dehydrogenase (IDH) gene is recurrently mutated in adult diffuse gliomas. IDH-mutant gliomas are categorized into oligodendrogliomas and astrocytomas, each with unique pathological features. Here, we use single-nucleus RNA and ATAC sequencing to compare the molecular heterogeneity of these glioma subtypes. In addition to astrocyte-like, oligodendrocyte progenitor-like, and cycling tumor...

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Identifiers

PMID: 37883975
DOI: 10.1016/j.xcrm.2023.101249
PMCID: PMC10694621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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