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Article

ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins

15 Dec 2016

Abstract excerpt

Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs (un-translated regions). The significance of editing within non-coding regions of RNA is poorly understood. Here, we demonstrate that association of ADAR2 with RNA stabilizes a subset of transcripts. ADAR2 interacts with and edits the 3΄UTR of...

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PMID: 28053121
DOI: 10.1093/nar/gkw1304

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