Article

LENG8 mediates RNA nuclear retention and degradation in eukaryotes

2025-08-16

Abstract excerpt

In eukaryotes, incompletely processed and misprocessed mRNAs as well as numerous noncoding RNAs are retained in the nucleus and often degraded. However, the mechanisms for this critical quality control pathway remain poorly understood. Here we identify LENG8 as a conserved RNA nuclear retention factor. We showed that LENG8 is recruited to pre-mRNAs by splicing factors, including the U1 snRNP. LENG8 binds to PCID2...

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Literature Corpus work: 3ce62441-10e6-5626-ad29-ab4c7a186309
DOI: 10.1101/2025.08.14.670437

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