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Article

Development of Polygenic Risk Score for Persistent Albuminuria in Children and Adults With Sickle Cell Anemia.

American journal of hematology - 1 Jun 2025

Zahr Rima S, Kang Guolian, Zhang Xu, Rashkin Sara R, Kovesdy Csaba P, Takemoto Clifford, Weiss Mitch, Lebensburger Jeffrey, Ataga Kenneth I, Saraf Santosh L

Abstract excerpt

Albuminuria is associated with high-risk apolipoprotein-L1 variants (APOL1 G1/G2) in patients with sickle cell anemia (SCA). However, this gene variant does not account for all chronic kidney disease (CKD) risk. We hypothesized that we could develop a polygenic risk score (PRS) for CKD in SCA, combining APOL1 G1/G2 with other candidate genes that modify SCA severity and further stratify patients into risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40186439
DOI: 10.1002/ajh.27678
PMCID: PMC12068958

Genes

APOL1
BCL11A
HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Development of Polygenic Risk Score for Persistent Albuminuria in Children and Adults With Sickle Cell Anemia.PMID 40186439Read ↗

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