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Article

Roles of APOL1 G1 and G2 variants in sickle cell disease patients: kidney is the main target.

British journal of haematology - 1 Oct 2017

Kormann Raphaël, Jannot Anne-Sophie, Narjoz Céline, Ribeil Jean-Antoine, Manceau Sandra, Delville Marianne, Joste Valentin, Prié Dominique, Pouchot Jacques, Thervet Eric, Courbebaisse Marie, Arlet Jean-Benoît

Abstract excerpt

In African-American patients with sickle cell disease (SCD), APOL1 G1 and G2 variants are associated with increased risk of sickle cell nephropathy (SCN). To determine the role of APOL1 variants in SCD patients living in Europe, we genotyped 152 SCD patients [aged 30·4 (24·3-36·4) years], mainly of Sub-Saharan African ancestry, for APOL1 G1 and G2 and for variants of four genes with kidney tropism (GSTM1, GSTT1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28699644
DOI: 10.1111/bjh.14842

Genes

APOL1
SCD
GSTM1
GSTP1
GSTT1
HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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