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Article

Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy.

Haematologica - 1 Oct 2015

Saraf Santosh L, Zhang Xu, Shah Binal, Kanias Tamir, Gudehithlu Krishnamurthy P, Kittles Rick, Machado Roberto F, Arruda Jose A L, Gladwin Mark T, Singh Ashok K, Gordeuk Victor R

Abstract excerpt

Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein. APOL1 G1/G2 variants are the strongest genetic predictors of kidney disease in the general African-American population. A single report associated APOL1 G1/G2 with sickle cell nephropathy. In 221 patients with sickle cell...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26206798
DOI: 10.3324/haematol.2015.124875
PMCID: PMC4591759

Genes

APOL1
HMOX1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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