Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia.

PloS one - 1 Jan 2016

Schaefer Beverly A, Flanagan Jonathan M, Alvarez Ofelia A, Nelson Stephen C, Aygun Banu, Nottage Kerri A, George Alex, Roberts Carla W, Piccone Connie M, Howard Thad A, Davis Barry R, Ware Russell E

Abstract excerpt

Discovery and validation of genetic variants that influence disease severity in children with sickle cell anemia (SCA) could lead to early identification of high-risk patients, better screening strategies, and intervention with targeted and preventive therapy. We hypothesized that newly identified genetic risk factors for the general African American population could also impact laboratory biomarkers known to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albuminuria
Share to Apolipoprotein L1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins

Share to Duffy Blood-Group System

Share to Glomerular Filtration Rate

Share to Hydroxyurea

Share to Leukocyte Count

Share to Lipoproteins, HDL

Source

Open in PubMed Open full text

Identifiers

PMID: 27711207
DOI: 10.1371/journal.pone.0164364
PMCID: PMC5053442

Genes

AGGF1
APOL1
CUBN
ZFHX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Modifiers of White Blood Cell Count, Albuminuria and Glomerular Filtration Rate in Children with Sickle Cell Anemia.PMID 27711207Read ↗

Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease.Semantic proximity Read ↗

Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children.Semantic proximity Read ↗

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Clinical and Genetic Predictors of Sickle Cell Nephropathy: A Global Systematic Review.Semantic proximity Read ↗

Genetic modifiers of sickle cell diseaseSemantic proximity Read ↗

Genetic modifiers of long‐term survival in sickle cell anemiaSemantic proximity Read ↗

Variation and impact of polygenic hematological traits in monogenic sickle cell diseaseSemantic proximity Read ↗

Genetics and Genomics in Sickle Cell Disease in Africa.Semantic proximity Read ↗

Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.Semantic proximity Read ↗

Local ancestry-aware genome-wide meta-analysis uncovers novel genetic loci for sickle cell disease nephropathySemantic proximity Read ↗

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.Semantic proximity Read ↗

The search for genetic modifiers of disease severity in the β-hemoglobinopathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.