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Article

The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia-Associated Kidney Function.

American journal of hematology - 1 Jun 2026

Rashkin Sara R, Kang Guolian, Takemoto Clifford M, Weiss Mitchell J, Ataga Kenneth I, Saraf Santosh L, Lebensburger Jeffrey, Zahr Rima S

Abstract excerpt

Progressive kidney injury is a major cause of morbidity and mortality in sickle cell anemia (SCA). The high risk APOL1 G1/G2 variants contribute to the development of kidney disease in individuals of African ancestry, including those with SCA. However, few studies have evaluated the longitudinal effect of APOL1 variants in children and young adults. We analyzed the association of APOL1 risk variants with kidney...

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Share to Anemia, Sickle Cell
Share to Apolipoprotein L1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41870384
DOI: 10.1002/ajh.70290
PMCID: PMC13139885

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia-Associated Kidney Function.PMID 41870384Read ↗

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