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Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia

31 Mar 2025

Abstract excerpt

Gamma Secretase Inhibitors (GSIs) effectively block oncogenic Notch homolog-1 (NOTCH1), a characteristic feature of T cell acute lymphoblastic leukemias (T-ALL). However, their clinical application has been stalled by the induction of severe gastrointestinal toxicity resulting from the inhibition of NOTCH signaling in the gut, which translates into increased goblet cell differentiation. Genome-wide CRISPR...

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PMID: 40163723
DOI: 10.1073/pnas.2426742122

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