Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Notch ligand Jagged1 as a target for anti-tumor therapy

1 Jan 2014

Abstract excerpt

The Notch pathway is increasingly attracting attention as a source of therapeutic targets for cancer. Ligand-induced Notch signaling has been implicated in various aspects of cancer biology; as a consequence, pan-Notch inhibitors and therapeutic antibodies targeting one or more of the Notch receptors have been investigated for cancer therapy. Alternatively, Notch ligands provide attractive options for therapy in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Developmental Biology and Gene Regulation
Share to Infectious Diseases and Mycology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25309874
DOI: 10.3389/fonc.2014.00254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Notch ligand Jagged1 as a target for anti-tumor therapyPMID 25309874Read ↗

Notch signaling pathway in cancer: from mechanistic insights to targeted therapiesSemantic proximity Read ↗

Notch Signaling in Cancer: Rationale and Strategies for TargetingSemantic proximity Read ↗

Notch Signaling Proteins: Legitimate Targets for Cancer TherapySemantic proximity Read ↗

Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive TumorsSemantic proximity Read ↗

NOTCH Signaling Pathway: Occurrence, Mechanism, and NOTCH-Directed Therapy for the Management of CancerSemantic proximity Read ↗

The multifaceted role of Notch in cancer.Semantic proximity Read ↗

Jagged1 (JAG1): Structure, expression, and disease associations.Semantic proximity Read ↗

Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy.Semantic proximity Read ↗

Notch signaling: An emerging therapeutic target for cancer treatmentSemantic proximity Read ↗

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancerSemantic proximity Read ↗

Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancerSemantic proximity Read ↗

NOTCH Signaling as a Novel Cancer Therapeutic TargetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.