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Article

SBNO2 is a critical mediator of STAT3-driven hematological malignancies

11 Jan 2023

Abstract excerpt

Gain-of-function mutations in the signal transducer and activator of transcription 3 (STAT3) gene are recurrently identified in patients with large granular lymphocytic leukemia (LGLL) and in some cases of natural killer (NK)/T-cell and adult T-cell leukemia/lymphoma. To understand the consequences and molecular mechanisms contributing to disease development and oncogenic transformation, we developed murine...

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PMID: 36630607
DOI: 10.1182/blood.2022018494

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