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Article

Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.

International journal of hematology - 1 Nov 2005

Aster Jon C

Abstract excerpt

Recent work has shown that the majority of human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) have gain-of-function mutations in NOTCH1, a type I transmembrane receptor that normally signals through a gamma-secretase-dependent mechanism that relies on ligand-induced regulated intramembranous proteolysis. Cleavage by gamma-secretase releases the intracellular domain of NOTCH1 (ICN1), permitting it to...

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Share to Dimerization
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia-Lymphoma, Adult T-Cell

Share to Lymphoma, T-Cell

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Share to Receptor, Notch1

Share to Signal Transduction

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Source

Identifiers

PMID: 16298817
DOI: 10.1532/IJH97.05096

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.PMID 16298817Read ↗

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T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.Semantic proximity Read ↗

The role of NOTCH1 signaling in T-ALL.Semantic proximity Read ↗

Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.Semantic proximity Read ↗

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disordersSemantic proximity Read ↗

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Notch signaling in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Targeting NOTCH1 in hematopoietic malignancy.Semantic proximity Read ↗

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