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Article

Novel NOTCH1-unmutated T-ALL Cell Line With Suppressed Growth by Gamma-secretase Inhibitors.

Anticancer research - 1 Jun 2026

Itoh Mai, Tohda Shuji

Abstract excerpt

BACKGROUND/AIM: T-cell acute lymphoblastic leukemia (T-ALL) frequently involves the activation of NOTCH1 signaling. However, effective NOTCH-directed therapies remain elusive. We established and characterized a novel T-ALL cell line, TMD11, lacking NOTCH mutations but sensitive to γ-secretase inhibitors (GSIs), providing a tool for discovering novel molecular targeted therapies. MATERIALS AND METHODS: TMD11 cells...

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Topics

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Share to Amyloid Precursor Protein Secretases
Share to Cell Line, Tumor
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Share to Signal Transduction

Share to Transcription Factor HES-1

Source

Identifiers

PMID: 42203317
DOI: 10.21873/anticanres.18179

Genes

HES1
MYC
NOTCH1
DLL1
DLL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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