Article
In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.
Haematologica - 1 Apr 2008
De Keersmaecker Kim, Lahortiga Idoya, Mentens Nicole, Folens Cedric, Van Neste Leander, Bekaert Sofie, Vandenberghe Peter, Odero Maria D, Marynen Peter, Cools Jan
Abstract excerpt
BACKGROUND: Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH1 signaling with gamma-secretase inhibitors causes cell cycle block, but only after treatment for several days. We further documented the effects of gamma-secretase inhibitor treatment on T-cell acute lymphoblastic leukemia cell lines and tested whether combining gamma-secretase inhibitors with other...
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