Article
Age- and ApoE Genotype-Dependent Transcriptomic Responses to O3 in the Hippocampus of Mice.
International journal of molecular sciences - 7 Mar 2025
Nakamya Mary F, Hu Kaili, Jiang Chunsun, Chong Zechen, Liu Rui-Ming
Abstract excerpt
Alzheimer's disease (AD) is a leading cause of dementia in the elderly, with late-onset AD (LOAD) accounting for 95% of the cases. The etiology underlying LOAD, however, remains unclear. Using a humanized mouse model, we showed previously that exposure to ozone (O3), a potential environment risk factor, in a cyclic exposure protocol that mimics a human exposure scenario, accelerated AD-like neuropathophysiology...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.