Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human APOE ɛ3 and APOE ɛ4 Alleles Have Differential Effects on Mouse Olfactory Epithelium.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Khan Naazneen, Alimova Yelena, Clark Sophie J, Vekaria Hemendra J, Walsh Adeline E, Williams Holden C, Hawk Gregory S, Sullivan Patrick G, Johnson Lance A, McClintock Timothy S

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a progressive age-dependent disorder whose risk is affected by genetic factors. Better models for investigating early effects of risk factors such as apolipoprotein E (APOE) genotype are needed. OBJECTIVE: To determine whether APOE genotype produces neuropathologies in an AD-susceptible neural system, we compared effects of human APOE ɛ3 (E3) and APOE ɛ4 (E4) alleles on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Olfactory Mucosa

Source

Open in PubMed Open full text

Identifiers

PMID: 34958025
DOI: 10.3233/JAD-215152
PMCID: PMC9052203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human APOE ɛ3 and APOE ɛ4 Alleles Have Differential Effects on Mouse Olfactory Epithelium.PMID 34958025Read ↗

Age- and ApoE Genotype-Dependent Transcriptomic Responses to O3 in the Hippocampus of Mice.Semantic proximity Read ↗

An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with CognitionSemantic proximity Read ↗

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s diseaseSemantic proximity Read ↗

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s diseaseSemantic proximity Read ↗

<i>APOE4</i> drives widespread changes to the hepatic proteome and alters metabolic functionSemantic proximity Read ↗

Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 MiceSemantic proximity Read ↗

An Alzheimer’s disease patient-derived olfactory cell model identifies gene expression changes associated with cognitionSemantic proximity Read ↗

Isoflurane and surgery aggravate APOE4-dependent lipid dysregulation and neural dysfunction, leading to neurological impairment in male miceSemantic proximity Read ↗

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Semantic proximity Read ↗

In vivo validation of late-onset Alzheimer's disease genetic risk factors.Semantic proximity Read ↗

Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brainSemantic proximity Read ↗

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.