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Aging, gender and <i>APOE</i> isotype modulate metabolism of Alzheimer's Aβ peptides and F<sub>2</sub>‐isoprostanes in the absence of detectable amyloid deposits

15 Jul 2004

Abstract excerpt

Aging and apolipoprotein E (APOE) isoform are among the most consistent risks for the development of Alzheimer's disease (AD). Metabolic factors that modulate risk have been elusive, though oxidative reactions and their by-products have been implicated in human AD and in transgenic mice with overt histological amyloidosis. We investigated the relationship between the levels of endogenous murine amyloid beta...

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PMID: 15287908
DOI: 10.1111/j.1471-4159.2004.02532.x

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