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Article

The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2021

Haghani Amin, Thorwald Max, Morgan Todd E, Finch Caleb E

Abstract excerpt

Little is known of gene-environment interactions for Alzheimer's disease (AD) risk factors. Apolipoprotein E (APOE) and neighbors on chromosome 19q13.3 have variants associated with risks of AD, but with unknown mechanism. This study describes novel links among the APOE network, air pollution, and age-related diseases. Mice exposed to air pollution nano-sized particulate matter (nPM) had coordinate responses of...

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Identifiers

PMID: 33215813
DOI: 10.1002/alz.12230
PMCID: PMC7914175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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