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Article

Integrative analysis reveals mouse strain-dependent responses to acute ozone exposure associated with airway macrophage transcriptional activity.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2022

Tovar Adelaide, Crouse Wesley L, Smith Gregory J, Thomas Joseph M, Keith Benjamin P, McFadden Kathryn M, Moran Timothy P, Furey Terrence S, Kelada Samir N P

Abstract excerpt

Acute ozone (O3) exposure is associated with multiple adverse cardiorespiratory outcomes, the severity of which varies across individuals in human populations and inbred mouse strains. However, molecular determinants of response, including susceptibility biomarkers that distinguish who will develop severe injury and inflammation, are not well characterized. We and others have demonstrated that airway macrophages...

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Identifiers

PMID: 34755540
DOI: 10.1152/ajplung.00237.2021
PMCID: PMC8721896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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