Article
Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2017
Chawanthayatham Supawadee, Valentine Charles C, Fedeles Bogdan I, Fox Edward J, Loeb Lawrence A, Levine Stuart S, Slocum Stephen L, Wogan Gerald N, Croy Robert G, Essigmann John M
Abstract excerpt
Aflatoxin B1 (AFB1) and/or hepatitis B and C viruses are risk factors for human hepatocellular carcinoma (HCC). Available evidence supports the interpretation that formation of AFB1-DNA adducts in hepatocytes seeds a population of mutations, mainly G:C→T:A, and viral processes synergize to accelerate tumorigenesis, perhaps via inflammation. Responding to a need for early-onset evidence predicting disease...
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