Article
The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis.
Carcinogenesis - 1 Apr 2001
Smela M E, Currier S S, Bailey E A, Essigmann J M
Abstract excerpt
Dietary exposure to aflatoxin B(1) (AFB(1)) is associated with an increased incidence of hepatocellular carcinoma (HCC), especially in populations in which exposure to hepatitis B virus (HBV) is a common occurrence. Most HCC samples from people living where HBV is prevalent have one striking mutational hotspot: a GC-->TA transversion at the third position of codon 249 of the p53 gene. In this review, the chemical...
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