Article

Genome-scale mutational signatures of aflatoxin in cells, mice and human tumors

2017-04-26

Abstract excerpt

Aflatoxin B1 (AFB1) is a mutagen and IARC Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here we present the first whole genome data on the mutational signatures of AFB1 exposure from a total of > 40,000 mutations in four experimental systems: two different human cell lines, and in liver tumors in wild-type mice and in mice that carried a hepatitis B surface antigen transgene – this to model the mu...

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Literature Corpus work: ebd5b800-d830-530f-a1c9-4490baca2231
DOI: 10.1101/130179

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