Article
Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.
Genome research - 1 Sept 2017
Huang Mi Ni, Yu Willie, Teoh Wei Wei, Ardin Maude, Jusakul Apinya, Ng Alvin Wei Tian, Boot Arnoud, Abedi-Ardekani Behnoush, Villar Stephanie, Myint Swe Swe, Othman Rashidah, Poon Song Ling, Heguy Adriana, Olivier Magali, Hollstein Monica, Tan Patrick, Teh Bin Tean, Sabapathy Kanaga, Zavadil Jiri, Rozen Steven G
Abstract excerpt
Aflatoxin B1 (AFB1) is a mutagen and IARC (International Agency for Research on Cancer) Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here, we present the first whole-genome data on the mutational signatures of AFB1 exposure from a total of >40,000 mutations in four experimental systems: two different human cell lines, in liver tumors in wild-type mice, and in mice that carried a hepatitis B...
Topics
- Aflatoxin B1
- Animals
- Carcinogens
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- China
- DNA Mutational Analysis
- Hepatitis B Surface Antigens
- Humans