Article

Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer’s disease

2020-11-18

Abstract excerpt

Abnormally phosphorylated tau, an indicator of Alzheimer’s disease, accumulates in the first decades of life in the locus coeruleus (LC), the brain’s main noradrenaline supply. However, technical challenges in reliable in-vivo assessments have impeded research into the role of the LC in Alzheimer’s disease. We studied participants with or known to be at-risk for mutations in genes causing autosomal-dominant Alzhei...

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Literature Corpus work: e4368513-46b0-5757-a12b-c45ed6d5191d
DOI: 10.1101/2020.11.16.20232561

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